4-Cyanothiophene-2-carboxylic acid → HCID 59339854, 화합물
반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][C@H:18]([C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=4)[C@@H:19]([NH2:21])[CH3:20])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[C:30]([C:32]1[CH:33]=[C:34]([C:37](O)=[O:38])[S:35][CH:36]=1)#[N:31]>>[C:30]([C:32]1[CH:33]=[C:34]([C:37]([NH:21][C@@H:19]([CH3:20])[C@H:18]([O:17][C:13]2[CH:12]=[C:11]3[C:16](=[CH:15][CH:14]=2)[N:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[N:9]=[CH:10]3)[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=2)=[O:38])[S:35][CH:36]=1)#[N:31]참가 물질
3
실험 절차
Prepared as described in Example 269 from (1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-(3-methoxyphenyl)propan-2-amine (6a, 70 mg, 0.18 mmol) and 4-cyanothiophene-2-carboxylic acid (32.9 mg, 0.21 mmol).
후처리
- customPrepared
출처 및 근거
- ORD 기록
- ord-4ae1f42eb04749588893755ae246767e
- 출처 데이터셋
- uspto-grants-2012_03