Hydrazine → HCID 59216351, 화합물

HRID 1099026노트

반응식

HRID 1099026 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]([O:14]C)=O)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[NH2:16][NH2:17]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]([NH:16][NH2:17])=[O:14])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 9321HydrazineHCID 13707544Methyl 1-(4-methoxyphenyl)-cyclopropanecarboxylate

생성물 1

HCID 59216351HCID 59216351, 화합물수율 83%

반응 조건

온도
120 °C

실험 절차

A mixture of methyl 1-(4-methoxyphenyl)cyclopropanecarboxylate (0.90 g, 4.4 mmol) and hydrazine (0.65 mL, 21 mmol) was heated at 120° C. for 2 h. After cooling, the excess hydrazine was removed under reduced pressure. The residue was treated with water, filtered and washed with water to give the desired product (750 mg, 83%). Analytical LCMS: (M+H)+=207.1.

후처리

  1. temperatureAfter cooling
  2. customthe excess hydrazine was removed under reduced pressure
  3. additionThe residue was treated with water
  4. filtrationfiltered
  5. washwashed with water

출처 및 근거

ORD 기록
ord-84f0b5683e2c429799fc3a50f43247ed
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143251B2

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