[(Aminocarbonyl)hydrazono](phenyl)acetaldehyde → 6-Phenyl-1,2,4-triazin-3(2H)-one

HRID 1099030노트

반응식

HRID 1099030 반응식
[NH2:1][C:2]([NH:4][N:5]=[C:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH:7]=O)=[O:3]>C(O)(=O)C>[C:9]1([C:6]2[CH:7]=[N:1][C:2](=[O:3])[NH:4][N:5]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

3

반응물 1

HCID 54444391[(Aminocarbonyl)hydrazono](phenyl)acetaldehyde

생성물 1

HCID 112637836-Phenyl-1,2,4-triazin-3(2H)-one수율 90.1%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

[(Aminocarbonyl)hydrazono](phenyl)acetaldehyde (3.00 g, 0.0157 mol) in acetic acid (15.0 mL) was heated at 130° C. for 6 h. After cooling, the solvent was removed under reduced pressure. The residue was triturated with ether, filtered, washed with ether, and dried under high vacuum to give the desired product (2.45 g, 90.1%). Analytical LCMS: (M+H)+=174.0.

후처리

  1. temperatureAfter cooling
  2. customthe solvent was removed under reduced pressure
  3. customThe residue was triturated with ether
  4. filtrationfiltered
  5. washwashed with ether
  6. customdried under high vacuum

출처 및 근거

ORD 기록
ord-7df081a83a6040e1878edd9837546375
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143251B2

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