Hydrazine → Methyl 1-(6-hydrazinopyridin-3-yl)cyclopropanecarboxylate

HRID 1099049노트

반응식

HRID 1099049 반응식
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2([C:11]([O:13][CH3:14])=[O:12])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[NH2:15][NH2:16]>N1C=CC=CC=1>[NH:15]([C:2]1[N:7]=[CH:6][C:5]([C:8]2([C:11]([O:13][CH3:14])=[O:12])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1)[NH2:16]

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 59216284Methyl 1-(6-chloro-3-pyridinyl)cyclopropanecarboxylate

생성물 1

HCID 59216299Methyl 1-(6-hydrazinopyridin-3-yl)cyclopropanecarboxylate수율 90%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
90 °C

실험 절차

To a solution of methyl 1-(6-chloropyridin-3-yl)cyclopropanecarboxylate (1 g, 0.005 mol) in pyridine (2 mL) was added hydrazine (0.30 mL, 0.0094 mol). The solution was heated at 90° C. overnight. The reaction solution was cooled to RT, and then diluted with a small amount of ice-water. The precipitate was collected by filtration, and dried under vacuum to afford the desired compound (0.9 g, 90%). Analytical LCMS: (M+H)+=208.0.

후처리

  1. temperatureThe reaction solution was cooled to RT
  2. filtrationThe precipitate was collected by filtration
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-f32fc3bfda1240cd82f91f903d076dea
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143251B2

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