2-Fluoroethanol → HCID 58019811, 화합물

HRID 1099106노트

반응식

HRID 1099106 반응식
CC(C)([O-])C.[K+].[Cl:7][C:8]1[CH:9]=[CH:10][C:11]2[N:12]=[C:13]([NH2:23])[N:14]=[C:15](N3C=NC=N3)[C:16]=2[N:17]=1.[F:24][CH2:25][CH2:26][OH:27]>C(Cl)Cl>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]2[N:12]=[C:13]([NH2:23])[N:14]=[C:15]([O:27][CH2:26][CH2:25][F:24])[C:16]=2[N:17]=1

참가 물질

5

반응물 3

HCID 97372-FluoroethanolHCID 23665647Potassium tert-butoxideHCID 576983146-Chloro-4-(1H-1,2,4-triazol-1-yl)pyrido[3,2-d]pyrimidin-2-amine

생성물 1

HCID 58019811HCID 58019811, 화합물수율 44%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Potassium tert-butoxide (2.8 mL; 1M in THF) was added to a suspension of 6-chloro-4-[1,2,4]triazol-1-yl-pyrido[3,2-d]pyrimidin-2-ylamine (0.7 g) and 2-fluoroethanol (0.83 mL) in DCM (100 mL). After stirring at room temperature for 10 minutes, the mixture was diluted with DCM (100 mL) and washed with brine. The organic layer was dried over Na2SO4 and concentrated to afford 6-chloro-4-(2-fluoro-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine as a yellow solid (0.3 g, yield: 44%) was characterized by its mass spectrum as follows: MS (m/z) 243.1 [M+H]+.

후처리

  1. washwashed with brine
  2. dry with materialThe organic layer was dried over Na2SO4
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ab240405354d4b41b3b09d9dcbd22a83
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143394B2

반응 노트

불러오는 중…