Sodium ethoxide → 6-Chloro-4-ethoxypyrido[3,2-d]pyrimidin-2-amine

HRID 1099109노트

반응식

HRID 1099109 반응식
[O-:1][CH2:2][CH3:3].[Na+].[Cl:5][C:6]1[CH:7]=[CH:8][C:9]2[N:10]=[C:11]([NH2:21])[N:12]=[C:13](N3C=NC=N3)[C:14]=2[N:15]=1>C1COCC1>[Cl:5][C:6]1[CH:7]=[CH:8][C:9]2[N:10]=[C:11]([NH2:21])[N:12]=[C:13]([O:1][CH2:2][CH3:3])[C:14]=2[N:15]=1

참가 물질

4

반응물 2

HCID 2723922Sodium ethoxideHCID 576983146-Chloro-4-(1H-1,2,4-triazol-1-yl)pyrido[3,2-d]pyrimidin-2-amine

생성물 1

HCID 597672176-Chloro-4-ethoxypyrido[3,2-d]pyrimidin-2-amine수율 79%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Sodium ethoxide (2.2 mL; 21 wt % in ethanol) was added to a suspension of 6-chloro-4-[1,2,4]triazol-1-yl-pyrido[3,2-d]pyrimidin-2-ylamine (1 g) in THF (50 mL). After stirring at room temperature for 30 minutes, THF was removed in vacuo and the residue was diluted with ethyl acetate (100 mL) and washed with brine. The organic layer was dried over Na2SO4 and concentrated to afford 6-chloro-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine as a beige solid (0.71 g, yield: 79%) which was characterized by its mass spectrum as follows: MS (m/z) 225.0 [M+H]+.

후처리

  1. customTHF was removed in vacuo
  2. additionthe residue was diluted with ethyl acetate (100 mL)
  3. washwashed with brine
  4. dry with materialThe organic layer was dried over Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-3ca786c5bfa34463bfe681a90590b011
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143394B2

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