Benzenepropanal → N-Hydroxy-N,3-diphenylpropanamide

HRID 1099333노트

반응식

HRID 1099333 반응식
C1CCN2C(=NCCC2)CC1.[C:12]1([CH2:18][CH2:19][CH:20]=[O:21])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[N:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:23]>ClCCl>[OH:23][N:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:20](=[O:21])[CH2:19][CH2:18][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 7707BenzenepropanalHCID 11473NitrosobenzeneHCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

생성물 1

HCID 12399704N-Hydroxy-N,3-diphenylpropanamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

DBU (15 mg, 0.1 mmol) was added under argon to a solution of 3-phenylpropanal (134 mg, 1 mmol), nitrosobenzene (107 mg, 1 mmol) and catalyst (36.4 mg, 0.1 mmol) in dichloromethane (5 mL). The reaction mixture was stirred at room temperature for 10 min. The solvent was removed under vacuum, and the residue was purified by flash silica gel column chromatography using hexane and ethyl acetate as the eluents.

후처리

  1. customThe solvent was removed under vacuum
  2. customthe residue was purified by flash silica gel column chromatography

출처 및 근거

ORD 기록
ord-06b8fb3c68ea4e9fa0051ebf209b07ba
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143423B2

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