Nitrosobenzene → (E)-N-hydroxy-3-(4-methoxyphenyl)-N-phenylacrylamide

HRID 1099339노트

반응식

HRID 1099339 반응식
C1CCN2C(=NCCC2)CC1.[CH3:12][O:13][C:14]1[CH:23]=[CH:22][C:17](/[CH:18]=[CH:19]/[CH:20]=[O:21])=[CH:16][CH:15]=1.[N:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:25]>ClCCl>[OH:25][N:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:20](=[O:21])/[CH:19]=[CH:18]/[C:17]1[CH:22]=[CH:23][C:14]([O:13][CH3:12])=[CH:15][CH:16]=1

참가 물질

5

반응물 3

HCID 11473NitrosobenzeneHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 641294p-METHOXYCINNAMALDEHYDE

생성물 1

HCID 14740422(E)-N-hydroxy-3-(4-methoxyphenyl)-N-phenylacrylamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

DBU (7.5 mg, 0.05 mmol) was added under argon to a solution of (E)-4-methoxycinnamaldehyde (162 mg, 1 mmol), nitrosobenzene (107 mg, 1 mmol) and catalyst (18.2 mg, 0.05 mmol) in dichloromethane (5 mL). The reaction mixture was stirred at room temperature for 10 min. The solvent was removed under vacuum, and the residue was purified by flash silica gel column chromatography using hexane and ethyl acetate as the eluents.

후처리

  1. customThe solvent was removed under vacuum
  2. customthe residue was purified by flash silica gel column chromatography

출처 및 근거

ORD 기록
ord-49154436f95d40fab3329f7a5798f36f
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143423B2

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