Triethylsilane → 2,3-Dihydro-4,7-dimethoxy-1H-indene
반응식
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:4]=1[CH2:5][CH2:6][C:7]2=O.C([SiH](CC)CC)C>FC(F)(F)C(O)=O>[CH3:13][O:12][C:9]1[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[C:4]2[C:8]=1[CH2:7][CH2:6][CH2:5]2참가 물질
4
실험 절차
To the cooled and stirred suspension of 4,7-Dimethoxyindan-1-one (35 gm, 0.182 mole) in Triethyl silane (105.7 gm, 0.909 mole), added Trifluoroacetic acid (350 ml) at 10-15° C. The stirring was continued at room temperature for 2 hours and quenched into the water. It was extracted with Ethyl acetate. The Ethyl acetate layer was washed with Sodium bicarbonate solution, dried over Sodium sulphate and evaporated to give crude mass which was purified by column chouromatography using 5% Ethyl acetate in hexane (22.5 gm).
후처리
- temperatureTo the cooled
- customquenched into the water
- extractionIt was extracted with Ethyl acetate
- washThe Ethyl acetate layer was washed with Sodium bicarbonate solution
- dry with materialdried over Sodium sulphate
- customevaporated
- customto give crude mass which
- customwas purified by column chouromatography
출처 및 근거
- ORD 기록
- ord-1dfd5092eeea4c69b50151328cf593ac
- 출처 데이터셋
- uspto-grants-2012_03
- 특허 번호
- US08143424B2
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