8-Methylcoumarin → 8-Methyl-3,4-dihydrocoumarin

HRID 1099363

반응식

HRID 1099363 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[O:10][C:9](=[O:12])[CH:8]=[CH:7]2.[H][H]>C(OCC)(=O)C.[Pd]>[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[O:10][C:9](=[O:12])[CH2:8][CH2:7]2

참가 물질

5

반응물 2

HCID 157348-MethylcoumarinHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 235130958-Methyl-3,4-dihydrocoumarin수율 90%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 8-Methyl coumarin (16.2 gm) in Ethyl acetate (160 ml), 10% w/w Palladium-charcoal (1.62 gm) was added. Hydrogenation was carried out for 5 hours at 55-60° C. in an autoclave at 240-250 psi. using Hydrogen gas. The reaction mixture was filtered through hyflow bed and distilled under vacuum to give a 14.5 gm of title compound as a white solid.

후처리

  1. filtrationThe reaction mixture was filtered through hyflow bed
  2. distillationdistilled under vacuum

출처 및 근거

ORD 기록
ord-b5ead7e6cea94f36a8394d61ca366f48
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143424B2

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