2-Chloro-6-methylpyrazine → HCID 25115599, 화합물

HRID 1099416노트

반응식

HRID 1099416 반응식
[CH2:1]([N:8]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C@H:9]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][C:16]=2B2OC(C)(C)C(C)(C)O2)[O:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:36]1[CH:41]=[N:40][CH:39]=[C:38]([CH3:42])[N:37]=1>>[CH2:28]([N:8]([CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C@H:9]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][C:16]=2[C:36]2[CH:41]=[N:40][CH:39]=[C:38]([CH3:42])[N:37]=2)[O:11][CH2:10]1)[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

참가 물질

3

반응물 2

HCID 71700952-Chloro-6-methylpyrazineHCID 25114260(S)-N,N-dibenzyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)chroman-3-amine

생성물 1

HCID 25115599HCID 25115599, 화합물수율 83%

실험 절차

The title compound was synthesized as described for Intermediate example I-28 in 83% yield starting from (S)-N,N-dibenzyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)chroman-3-amine and 2-chloro-6-methylpyrazine (1.1 equiv); 1H NMR (400 MHz, DMSO-d6) δ ppm 8.59 (s, 1 H), 8.54-8.56 (m, 1 H), 7.24-7.34 (m, 8 H), 7.16-7.22 (m, 3 H), 6.99 (dd, 1 H), 6.86 (dd, 1 H), 4.31-4.37 (m, 1 H), 4.07 (t, 1 H), 3.64-3.73 (m, 4 H), 3.12-3.21 (m, 1 H), 2.92-3.02 (m, 1 H), 2.64-2.73 (m, 1 H), 2.55 (s, 3 H); MS (APPI/APCI) m/z 422[M+H+].

출처 및 근거

ORD 기록
ord-763faf7d3914432497d0ff0a7dd64649
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143408B2

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