Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methoxybenzenesulfonyl chloride → tert-butyl N-[4-[[[(6S)-3-[(4-methoxyphenyl)sulfonylamino]-4-oxo-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidine-6-carbonyl]amino]methyl]benzenecarboximidoyl]carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methoxybenzenesulfonyl chloride | HCID 7401 | — |
| 반응물 | tert-butyl N-[4-[[[(6S)-3-(methanesulfonamido)-4-oxo-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidine-6-carbonyl]amino]methyl]benzenecarboximidoyl]carbamate | HCID 145857232 | — |
| 반응물 | tert-butyl N-[4-[[[(6S)-3-(diethylamino)-4-oxo-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidine-6-carbonyl]amino]methyl]benzenecarboximidoyl]carbamate | HCID 145857233 | — |
| 생성물 | tert-butyl N-[4-[[[(6S)-3-[(4-methoxyphenyl)sulfonylamino]-4-oxo-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidine-6-carbonyl]amino]methyl]benzenecarboximidoyl]carbamate | HCID 145857229 | 46.2% |
반응 단계
Following a procedure similar to that for the preparation of 16a, intermediate 3a (50 mg, 0.117 mmol) and 4-methoxybenzene sulfonyl chloride (31.4 mg, 0.152 mmol) yielded 32.2 mg (46.2%) of 31a. MS (ESI) 597.0 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07094783B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-ab7d74dafc3f48528fad4da7326d5315 |
| 출처 메모 | uspto-grants-2006_08 |