(6R,8S)-[3-(allyl-benzyloxycarbonyl-amino)-6-(tert-butoxycarbonyl-phenyl-aminocarbonyl)-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl]-acetic Acid tert-butyl Ester → (6R,8S)-3-(allyl-benzyloxycarbonyl-amino)-8-tert-butoxycarbonylmethyl-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic acid
반응식
[CH2:1]([N:4]([C:22]([O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:23])[C:5]1[C:10](=[O:11])[N:9]2[C@H:12]([C:19]([OH:21])=[O:20])[CH2:13][C@:14](N=[N+]=[N-])([CH3:15])[C:8]2=[N:7][CH:6]=1)[CH:2]=[CH2:3].[C:32]([O:36][C:37](=[O:80])[CH2:38][C@@]1(C)C2=NC=C(N(CC=C)C(OCC3C=CC=CC=3)=O)C(=O)N2[C@@H](C(N(C(OC(C)(C)C)=O)C2C=CC=CC=2)=O)C1)([CH3:35])([CH3:34])[CH3:33]>>[CH2:1]([N:4]([C:22]([O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:23])[C:5]1[C:10](=[O:11])[N:9]2[C@@H:12]([C:19]([OH:21])=[O:20])[CH2:13][C@:14]([CH2:38][C:37]([O:36][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:80])([CH3:15])[C:8]2=[N:7][CH:6]=1)[CH:2]=[CH2:3]참가 물질
3
반응물 2
HCID 69600731(6R,8S)-[3-(allyl-benzyloxycarbonyl-amino)-6-(tert-butoxycarbonyl-phenyl-aminocarbonyl)-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl]-acetic Acid tert-butyl Ester
HCID 86590672(6S,8R)-3-(allyl-benzyloxycarbonyl-amino)-8-azido-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid생성물 1
실험 절차
According to the procedure for the preparation of 18f, intermediate 38b (413.9 mg, 0.62 mmol) was deprotected to afford 273.9 mg (89%) of intermediate 38c. MS (ESI) 498.4 (M+H+), 496.2 (M−H+).
출처 및 근거
- ORD 기록
- ord-f48e92db5f75411fa21ca293595467aa
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07094783B2
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