HCID 91233536, 화합물 → 4-(2-Chlorophenyl)-6-(2-hydroxyethyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

HRID 11041노트

반응식

HRID 11041 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH:20]2[C:21](=[O:25])[NH:22][C:23](=[O:24])[CH:19]2[C:18]2[C:17]3[CH:16]=[C:15]([O:26][CH3:27])[CH:14]=[CH:13][C:12]=3[N:11]([CH2:28][CH2:29][OH:30])[C:10]=2[CH2:9]1>O=[Mn]=O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:20]2[C:21](=[O:25])[NH:22][C:23](=[O:24])[C:19]=2[C:18]2[C:17]3[CH:16]=[C:15]([O:26][CH3:27])[CH:14]=[CH:13][C:12]=3[N:11]([CH2:28][CH2:29][OH:30])[C:10]=2[CH:9]=1

참가 물질

3

반응물 1

HCID 91233536HCID 91233536, 화합물

생성물 1

HCID 867601884-(2-Chlorophenyl)-6-(2-hydroxyethyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione수율 72%

시약·촉매·용매 1

HCID 14801Manganese dioxide촉매

실험 절차

4-(2-Chlorophenyl)-6-(2-hydroxyethyl)-9-methoxy-4,5,6,10c-tetrahydropyrrolo[3,4-c]carbazole-1,3(2H, 3aH)-dione (IV; Ar=2-chlorophenyl, R10═CH2CH2OH) (45) prepared according to example 42 was reacted with MnO2 using the procedure described in example 79 except that the reaction time was 18 h gave 4-(2-Chlorophenyl)-6-(2-hydroxyethyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione (V; Ar=2-chlorophenyl, R10═CH2CH2OH) (46) in a 72% yield as a yellow powder, mp 255–257° C. 1H NMR δ [(CD3)2SO] 11.10 (br s, 1H), 8.52 (d, J=2.6 Hz, 1H), 7.80 (s, 1H), 7.71 (d, J=9.0 Hz, 1H), 7.59–7.56 (m, 1H), 7.52–7.43 (m, 4H), 7.29 (dd, J=9.0, 2.2.6 Hz, 1H), 4.84 (t, J=5.0 Hz, 1H), 4.53 (t, J=5.2 Hz, 2H), 3.90 (s, 3H), 3.77 (m, 2H). Found: C, 65.50; H, 4.07; N, 6.59. C23H17ClN2O4 requires C, 65.64; H, 4.07; N, 6.66.

출처 및 근거

ORD 기록
ord-f1b9ba14d3e54230a51534c4c554d328
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094798B1

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