Acetyl isothiocyanate → HCID 13023177, 화합물

HRID 1105833노트

반응식

HRID 1105833 반응식
[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH2:22])[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2].[C:24]([N:27]=[C:28]=[S:29])(=[O:26])[CH3:25]>CC(C)=O>[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH:22][C:28]([NH:27][C:24](=[O:26])[CH3:25])=[S:29])[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2]

참가 물질

4

반응물 2

HCID 128851Acetyl isothiocyanateHCID 30369724-Amino-3-(3'-methoxycarbonyl-2'-thioureido)benzophenone

생성물 1

HCID 13023177HCID 13023177, 화합물수율 54%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a suspension of 3-(3-carbomethoxythioureido)-4-aminobenzophenone (1.2 g.; 0.0036 mole) in acetone (15 ml.) is added acetyl isothiocyanate (0.37 g.; 0.0036 mole). The reaction mixture is heated to reflux and then allowed to stand at room temperature for 18 hours. The product is collected by filtration, washed successively to afford 0.85 g. (54% yield) of 3-(3-carbomethoxythioureido)-4-(3-acetylthioureido)benzophenone, m.p. 210° C., dec.

후처리

  1. temperatureThe reaction mixture is heated
  2. temperatureto reflux
  3. filtrationThe product is collected by filtration
  4. washwashed successively
  5. customto afford 0.85 g

출처 및 근거

ORD 기록
ord-e84afdf185344eae9b18d65a1ee6ca8c
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04310537

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