p-Toluenesulfonyl isocyanate → HCID 13023179, 화합물

HRID 1105835노트

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HRID 1105835 반응식
[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH2:22])[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2].[C:24]1([CH3:36])[CH:29]=[CH:28][C:27]([S:30]([N:33]=[C:34]=[O:35])(=[O:32])=[O:31])=[CH:26][CH:25]=1>CC(C)=O>[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH:22][C:34]([NH:33][S:30]([C:27]1[CH:28]=[CH:29][C:24]([CH3:36])=[CH:25][CH:26]=1)(=[O:32])=[O:31])=[O:35])[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2]

참가 물질

4

반응물 2

HCID 77703p-Toluenesulfonyl isocyanateHCID 30369724-Amino-3-(3'-methoxycarbonyl-2'-thioureido)benzophenone

생성물 1

HCID 13023179HCID 13023179, 화합물수율 29%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
50 °C

실험 절차

To a suspension of 3-(3-carbomethoxythioureido)-4-aminobenzophenone (1.0 g.; 0.00304 mole) in acetone (5 ml.) is added p-toluenesulfonyl isocyanate (0.6 g.; 0.00304 mole). The suspension is heated to 50° C. and vacuum filtered. The precipitate is washed with acetone and ether and then dried to afford 0.4 g. (29% yield) of 3-(3-carbomethoxythioureido)-4-(3-p-toluenesulfonylureido)benzophenone, m.p. 191°-192° C., dec.

후처리

  1. filtrationvacuum filtered
  2. washThe precipitate is washed with acetone and ether
  3. customdried
  4. customto afford 0.4 g

출처 및 근거

ORD 기록
ord-a25c16c82c6e4e15a25ad8df1f56df23
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04310537

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