Ethanol → Ethyl 2-[4-(4-chlorophenyl)benzyloxy]-2-phenylacetate

HRID 1105873노트

반응식

HRID 1105873 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:25]=[CH:24][C:11]([CH2:12][O:13][CH:14]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.S(=O)(=O)(O)O.C(=O)(O)[O-].[CH2:35](O)[CH3:36]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:25]=[CH:24][C:11]([CH2:12][O:13][CH:14]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:15]([O:17][CH2:35][CH3:36])=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 4

HCID 702EthanolHCID 769Bicarbonate IonHCID 1118Sulfuric AcidHCID 98633512-[4-(4-Chlorophenyl)benzyloxy]-2-phenylacetic acid

생성물 1

HCID 20555293Ethyl 2-[4-(4-chlorophenyl)benzyloxy]-2-phenylacetate

실험 절차

A solution of 2-[4-(4-chlorophenyl)benzyloxy]-2-phenylacetic acid (8.0 g.) in ethanol (200 ml.) containing concentrated sulphuric acid (1 ml.) was heated under reflux for 90 minutes, then cooled to room temperature, and carefully neutralised by addition of an excess of saturated aqueous bicarbonate solution. The mixture obtained was evaporated and the residue extracted thoroughly with ethyl acetate. The combined extracts were washed with water, dried (MgSO4) and evaporated to give ethyl 2-[4-(4-chlorophenyl)benzyloxy]-2-phenylacetate (6.65 g.), m.p. 50°-51° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 90 minutes
  3. customThe mixture obtained
  4. customwas evaporated
  5. extractionthe residue extracted thoroughly with ethyl acetate
  6. washThe combined extracts were washed with water
  7. dry with materialdried (MgSO4)
  8. customevaporated

출처 및 근거

ORD 기록
ord-849d0e41554c4a528911e78e602a55cf
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04310544

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