4-Toluenesulfonyl chloride → 2,2-Dimethyl-4-(4-p-toluenesulfonyloxybutyl)-1,3-dioxolane

HRID 1105987노트

반응식

HRID 1105987 반응식
[CH3:1][C:2]1([CH3:12])[O:6][CH:5]([CH2:7][CH2:8][CH2:9][CH2:10][OH:11])[CH2:4][O:3]1.[C:13]1([CH3:23])[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1>N1C=CC=CC=1>[CH3:1][C:2]1([CH3:12])[O:6][CH:5]([CH2:7][CH2:8][CH2:9][CH2:10][O:11][S:19]([C:16]2[CH:17]=[CH:18][C:13]([CH3:23])=[CH:14][CH:15]=2)(=[O:21])=[O:20])[CH2:4][O:3]1

참가 물질

4

반응물 2

HCID 73974-Toluenesulfonyl chlorideHCID 2366824-(2,2-Dimethyl-1,3-dioxolan-4-yl)butan-1-ol

생성물 1

HCID 127708652,2-Dimethyl-4-(4-p-toluenesulfonyloxybutyl)-1,3-dioxolane

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a stirred, ice-cold solution of 6.97 g. of 2,2-dimethyl-4-(4-hydroxybutyl)-1,3-dioxolane [Chem. Abstr., 67, 32617f (1967)] in 40 ml. of pyridine is added 9.2 g. of p-toluenesulfonyl chloride. The mixture is kept at 0°-5° C. overnight, diluted with ice water, and extracted with ether. The extract is washed successively with water, sodium bicarbonate, water, and brine. The extract is dried over magnesium sulfate and concentrated to give a syrup; pmr (CDCl3) δ 2.50 (singlet).

후처리

  1. extractionextracted with ether
  2. washThe extract is washed successively with water, sodium bicarbonate, water, and brine
  3. dry with materialThe extract is dried over magnesium sulfate
  4. concentrationconcentrated
  5. customto give a syrup

출처 및 근거

ORD 기록
ord-79e7d7a30016416f8a7ec2e3b8fe477d
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04310700

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