Dimethylformamide → HCID 178474808, 화합물

HRID 1106113

반응식

HRID 1106113 반응식
[C:1]([NH:4][CH2:5][CH2:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:21]=[C:20]([OH:22])[C:19]([C:23]([OH:25])=[O:24])=[CH:18][N:17]=2)=[CH:12][CH:11]=1)=[O:8])(=[O:3])[CH3:2].CN(C)C=O.C(N1C=CN=C1)(N1C=CN=C1)=O.C(#N)C>CCOCC>[N-:21]1[CH:20]=[CH:19][N:17]=[CH:16]1.[C:1]([NH:4][CH2:5][CH2:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:21]=[C:20]([OH:22])[C:19]([C:23]([OH:25])=[O:24])=[CH:18][N:17]=2)=[CH:12][CH:11]=1)=[O:8])(=[O:3])[CH3:2]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 6342AcetonitrileHCID 682631,1'-CarbonyldiimidazoleHCID 178474807HCID 178474807, 화합물

생성물 1

HCID 178474808HCID 178474808, 화합물수율 185.6%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A suspension of 5.7 g (16.5 mmol) of the above pyrimidine acid, 20 ml of dimethylformamide, and 5.7 g (35.1 mmol) of carbonyldiimidazole is stirred at 50°-60° C. for 30 minutes and 3 hrs at room temperature. Acetonitrile (40 ml) and ether (40 ml) are added and the product filtered, washed with acetonitrile, ether, and dried to give 6.3 g of the title imidazolide.

후처리

  1. filtrationthe product filtered
  2. washwashed with acetonitrile, ether
  3. customdried

출처 및 근거

ORD 기록
ord-343b2904df6c4bfc8baee8db4441b9a0
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04311699

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