Dimethylformamide → HCID 178475082, 화합물

HRID 1106121노트

반응식

HRID 1106121 반응식
[C:1]([NH:4][C@@H:5]([C:9]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[N:23]=[C:22]([OH:24])[C:21]([C:25]([OH:27])=[O:26])=[CH:20][N:19]=2)=[CH:14][CH:13]=1)=[O:10])[CH:6]([CH3:8])[CH3:7])(=[O:3])[CH3:2].C(N1C=CN=C1)(N1C=CN=C1)=O.CN(C)C=O.O1CCCC1>CCOCC>[N-:23]1[CH:22]=[CH:21][N:19]=[CH:18]1.[C:1]([NH:4][C@@H:5]([C:9]([NH:11][C:12]1[CH:13]=[CH:14][C:15]([C:18]2[N:23]=[C:22]([OH:24])[C:21]([C:25]([OH:27])=[O:26])=[CH:20][N:19]=2)=[CH:16][CH:17]=1)=[O:10])[CH:6]([CH3:8])[CH3:7])(=[O:3])[CH3:2]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 682631,1'-CarbonyldiimidazoleHCID 178475081HCID 178475081, 화합물

생성물 1

HCID 178475082HCID 178475082, 화합물수율 119.7%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of 3.72 g (10 mmol) of the above pyrimidine acid, 3.24 g (20 mmol) of carbonyldiimidazole, and 25 ml of dimethylformamide is stirred at 49°-52° C. for 30 min. The solution is treated with 50 ml of tetrahydrofuran and 200 ml of ether and stored in the cold overnight. The solid is filtered, washed with ether and dried to give 2.63 g of the title imidazolide.

후처리

  1. customstored in the cold overnight
  2. filtrationThe solid is filtered
  3. washwashed with ether
  4. customdried

출처 및 근거

ORD 기록
ord-d903c78d1c674dc4ab52fe6ef1beb73c
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04311699

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