Isopropylamine → N-Isopropyl-p-vinylphenethylamine

In a 300 ml four necked flask equipped with a thermometer, a reflux condenser, an inlet for nitrogen and a stirrer were charged 1860 ml of dry n-hexane and 148 g of iso-propylamine. While stirring the mixture, 119 ml of a 15% n-butyllithium n-hexane solution were added dropwise thereto. During the addition, the temperature was maintained at 5° C. to 7° C. The color of the solution was changed from colorless to pale yellow. After 10 minutes, 325 g of p-divinylbenzene having a purity of 96% were added to the mixture, whereby the color of the reaction mixture was changed to brown. Then, the inner temperature was elevated to 45° C., at which the reaction was continued for 6 hours. After the reaction, the reaction was terminated with ethanol and the solvent was evaporated. The residue was poured into 2 l of n-hexane and the insoluble are filtered off, followed by evaporation and distillation, whereby there were obtained 230 g of the product having a boiling point of 62° C.-64° C./0.08 mmHg.

1. additionwere added dropwise
2. additionDuring the addition
3. temperaturethe temperature was maintained at 5° C. to 7° C
4. customwas elevated to 45° C., at which
5. waitwas continued for 6 hours
6. customAfter the reaction
7. customthe reaction was terminated with ethanol
8. customthe solvent was evaporated
9. additionThe residue was poured into 2 l of n-hexane
10. filtrationthe insoluble are filtered off
11. customfollowed by evaporation and distillation

ORD 기록

ord-f9a5bc7a1a1643b194ed7fc5edc01fce

출처 데이터셋

uspto-grants-1982_01

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US04311799