4-Methyloxybenzyl chloride → 1-(4-Methoxybenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine

반응식

[OH:1][CH:2]([CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.[CH3:28][O:29][C:30]1[CH:37]=[CH:36][C:33]([CH2:34]Cl)=[CH:32][CH:31]=1>>[CH3:28][O:29][C:30]1[CH:37]=[CH:36][C:33]([CH2:34][N:7]2[CH2:8][CH2:9][N:4]([CH2:3][CH:2]([OH:1])[CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:5][CH2:6]2)=[CH:32][CH:31]=1

참가 물질

반응물 2

HCID 699934-Methyloxybenzyl chloride

HCID 130377901-(2-Hydroxy-3-n-hexadecyloxypropyl)-piperazine

생성물 1

HCID 130377981-(4-Methoxybenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine

실험 절차

Following the procedure of Example 5, 1-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine was reacted with 4-methoxybenzyl chloride to form 1-(4-methoxybenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine, mp 233°-245° C.

출처 및 근거

ORD 기록: ord-e2370a41be9d42bdb7ab5ce4457c3572
출처 데이터셋: uspto-grants-1982_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04312877

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