Acetone → 1-(2-Hydroxy-3-n-hexadecyloxypropyl)-4-phenylpiperidine

HRID 1106280노트

반응식

[C:1]1([CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O1CC1C[CH:16]([O:32][CH:33]([CH2:49][CH:50]1OC1)CCCCCCCCCCCCCCC)[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31].CC(C)=[O:56]>>[OH:56][CH:49]([CH2:33][O:32][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[CH2:50][N:10]1[CH2:9][CH2:8][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:12][CH2:11]1

참가 물질

반응물 3

HCID 180Acetone

HCID 698734-Phenylpiperidine

HCID 180000852,3-Epoxypropyl-n-hexadecylether

생성물 1

HCID 130378071-(2-Hydroxy-3-n-hexadecyloxypropyl)-4-phenylpiperidine수율 50%

반응 조건

온도: 180 °C

실험 절차

4-Phenylpiperidine (1.8 g, 0.011 mol) and 2,3-epoxypropyl-n-hexadecylether (2.98 g, 0.01 mol) were combined and heated to 180° C. for 30 minutes. The reaction mixture was cooled, acetone was added, and the mixture was stirred for 16 hours. The resulting solids were collected and recrystallized from hot acetone to give pure product (2.3 g, 50% yield): mp 64°-65° C.

후처리

temperatureThe reaction mixture was cooled
customThe resulting solids were collected
customrecrystallized from hot acetone

출처 및 근거

ORD 기록: ord-207c117be1824010b98f68cbc36017a4
출처 데이터셋: uspto-grants-1982_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04312877

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