Sulfuric Acid → HCID 53778393, 화합물

HRID 1106284노트

반응식

HRID 1106284 반응식
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH2:13])(=[O:12])=[O:11])=[CH:6][CH:5]=1)(=O)C.O.[C:15]([OH:19])(=[O:18])[CH:16]=O.OS(O)(=O)=O.[O:25]1[CH2:30][CH2:29]OCC1>O>[NH2:13][S:10]([C:7]1[CH:8]=[CH:9][C:4]([CH2:1][C:30](=[O:25])[CH:29]=[CH:16][C:15]([OH:19])=[O:18])=[CH:5][CH:6]=1)(=[O:11])=[O:12]

참가 물질

6

반응물 4

HCID 1118Sulfuric AcidHCID 312751,4-DioxaneHCID 740654-AcetylbenzenesulphonamideHCID 15620607Glyoxylic acid, monohydrate2회

생성물 1

HCID 53778393HCID 53778393, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 37 g of p-acetylbenzenesulfonamide, 78.4 g of glyoxylic acid hydrate, 20 ml of 80% H2SO4 and 180 ml of dioxane is refluxed for 24 hours. An additional 10 g of glyoxylic acid hydrate is added and the mixture is refluxed for 24 hours. The reaction mixture is poured into 2 liters of water and extracted with ether. The organic layers are combined, dried, and evaporated to leave a solid which is crystallized from acetonitrile yielding 10.9 g of the title compound, melting point 180°-181° C.

후처리

  1. temperatureis refluxed for 24 hours
  2. temperaturethe mixture is refluxed for 24 hours
  3. extractionextracted with ether
  4. customdried
  5. customevaporated
  6. customto leave a solid which
  7. customis crystallized from acetonitrile yielding 10.9 g of the title compound, melting point 180°-181° C.

출처 및 근거

ORD 기록
ord-8f5b4e3dcabe4666b42b5aa22fe64daf
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04312990

반응 노트

불러오는 중…