Methanol → HCID 13022911, 화합물

HRID 1106285노트

반응식

HRID 1106285 반응식
[NH2:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12](=O)[CH:13]=[CH:14]C(O)=O)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[NH2:19][NH2:20].[OH-:21].[K+].C[OH:24]>>[NH2:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH2:12][CH:13]([C:14]([OH:24])=[O:21])[NH:20][N:19]=2)=[CH:9][CH:10]=1)(=[O:3])=[O:4]

참가 물질

5

반응물 4

HCID 887MethanolHCID 9321HydrazineHCID 14797Potassium HydroxideHCID 53778393HCID 53778393, 화합물

생성물 1

HCID 13022911HCID 13022911, 화합물

실험 절차

A mixture of 12.75 g of 5-[4-(aminosulfonyl)phenyl]-4-oxo-2-pentenoic acid, 2.24 g of hydrazine and 3.0 g of KOH in 100 ml of methanol is refluxed for 3 hours, cooled, and 50 ml of methanol is removed in vacuo. Then there is added 50 ml of water and the mixture is acidified with concentrated HCl. The resulting solid is filtered off, washed with water, then ethanol and dried to yield 8.8 g of the title compound, melting point 224°-226° C.

후처리

  1. temperatureis refluxed for 3 hours
  2. temperaturecooled
  3. custom50 ml of methanol is removed in vacuo
  4. additionThen there is added 50 ml of water
  5. filtrationThe resulting solid is filtered off
  6. washwashed with water
  7. dry with materialethanol and dried

출처 및 근거

ORD 기록
ord-692eb696e089476295df58e8fc114323
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04312990

반응 노트

불러오는 중…