Ethylene Glycol → 2-(2-Bromoethyl)-2-methyl-1,3-dioxolane
반응식
[Br:1][CH2:2][CH2:3][C:4](=[O:6])[CH3:5].[CH2:7](O)[CH2:8][OH:9].C1(C)C=CC(S(O)(=O)=O)=CC=1.C(=O)([O-])[O-].[K+].[K+]>C(OCC)(=O)C.O.C1(C)C=CC=CC=1>[CH2:8]1[O:9][C:4]([CH2:3][CH2:2][Br:1])([CH3:5])[O:6][CH2:7]1참가 물질
8
실험 절차
A mixture of 75 g of 4-bromo-2-butanone, 40 g of ethylene glycol, 250 mg of p-toluenesulfonic acid acid and 500 ml of toluene is refluxed for about 4-6 hours under a Dean-Stark water trap. The mixture is cooled, poured into ethyl acetate and dilute potassium carbonate solution. The organic layer is separated, washed with water, dried over sodium sulfate, stripped of solvent and the residue is distilled under reduced pressure to give the title product.
후처리
- temperatureThe mixture is cooled
- customThe organic layer is separated
- washwashed with water
- dry with materialdried over sodium sulfate
- distillationthe residue is distilled under reduced pressure
출처 및 근거
- ORD 기록
- ord-5579699143fc4414b844206821a3455e
- 출처 데이터셋
- uspto-grants-1982_01
- 특허 번호
- US04312994
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