Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → 1-(2-Amino-1-oxo-3-phenylpropyl)-4-(4-fluorophenyl)piperazine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| 반응물 | 1,1-Dimethylethyl 2-(4-(4-fluorophenyl)-1-piperazinyl)-2-oxo-1-(phenylmethyl)ethylcarbamate | HCID 53804735 | — |
| 생성물 | 1-(2-Amino-1-oxo-3-phenylpropyl)-4-(4-fluorophenyl)piperazine hydrochloride | HCID 18545010 | 96.1% |
반응 단계
To a solution of 1,1-dimethylethyl 2-(4-(4-fluorophenyl)-1-piperazinyl)-2-oxo-1-(phenylmethyl)ethylcarbamate (2.7 g, 6.3 mmol) in ethyl acetate (20 mmol) under ice-cooling was dropwise added 4N HCl/ethyl acetate (20 ml), and the mixture was stirred at room temperature overnight. The resulting crystals were recovered by filtration and recrystallized from ethanol-diethyl ether to give 1-(2-amino-1-oxo-3-phenylpropyl)-4-(4-fluorophenyl)piperazine hydrochloride (2.2 g, 96.1%) as pale-yellow crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06057290 |
| 출처 데이터셋 | uspto-grants-2000_05 |
| ORD ID | ord-4ed625e9de4341d092adb9d460a29452 |
| 출처 메모 | uspto-grants-2000_05 |