HCID 21968280, 화합물 → HCID 21968279, 화합물

HRID 1106508노트

반응식

HRID 1106508 반응식
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]2[NH:8][C@@H:7]3[CH2:12][CH2:13][N:14](CC4C=CC=CC=4)[CH2:15][C@H:6]3[C:5]=2[CH:4]=1.[H][H]>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]2[NH:8][C@@H:7]3[CH2:12][CH2:13][NH:14][CH2:15][C@H:6]3[C:5]=2[CH:4]=1

참가 물질

5

반응물 2

HCID 21968280HCID 21968280, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 21968279HCID 21968279, 화합물수율 78%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of intermediate 8 (11.3 g) in methanol (250 ml) was hydrogenated with palladium-on-carbon (10%, 2 g) as a catalyst. After uptake of hydrogen (1 equivalent), the catalyst was filtered off and the filtrate was evaporated. The residue was solidified in DIPE (30 ml). The precipitate was filtered off and dried, yielding 6.1 g (78%) of (±)-trans-2,3,4,4a,5,9b-hexahydro-8-methoxy-1H-pyrido[4,3-b]indole (intermediate 10).

후처리

  1. customthe filtrate was evaporated
  2. filtrationThe precipitate was filtered off
  3. customdried

출처 및 근거

ORD 기록
ord-101d16f8f0d4451f89cd84ce1543db2d
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06057325

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