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Dimethylformamide → (4-Benzyloxy-3-nitro-phenoxy)-acetonitrile

HRID 1106732
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인쇄 미리보기

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HRID 1106732 반응식
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][C:8]#[N:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].CN(C)C=O.C(=O)([O-])[O-].[K+].[K+].[CH2:26](Br)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>C(OCC)(=O)C>[CH2:26]([O:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][C:8]#[N:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 18789604(4-Hydroxy-3-nitro-phenoxy)-acetonitrile

생성물 1

HCID 18789746(4-Benzyloxy-3-nitro-phenoxy)-acetonitrile수율 80.4%

시약·촉매·용매 1

HCID 8857
Ethyl Acetate
용매

반응 조건

온도
70 °C

실험 절차

A heterogeneous mixture of 6.0 g of (4-hydroxy-3-nitro-phenoxy)-acetonitrile, 50 ml N,N-dimethylformamide, 12.8 g of potassium carbonate, and 5.8 g of benzyl bromide was heated with stirring at 70° C. for 22 hours. The mixture was cooled to room temperature, poured into ethyl acetate, washed with water, washed with 1N sodium hydroxide, again with water, dried (MgSO4), evaporated, and obtained 7.06 g of (4-benzyloxy-3-nitro-phenoxy)-acetonitrile as a tan solid.

후처리

  1. temperaturewas heated
  2. temperatureThe mixture was cooled to room temperature
  3. washwashed with water
  4. washwashed with 1N sodium hydroxide, again with water
  5. dry with materialdried (MgSO4)
  6. customevaporated

출처 및 근거

ORD 기록
ord-01dc3a32a540408ca9b6d8c1498c25ce
출처 데이터셋
uspto-grants-2000_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06057349

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