t-Butyl 4-phenyl-2-butenoate → 4-Phenyl-2-butenoic acid

HRID 1107112노트

반응식

HRID 1107112 반응식
[C:1]1([CH2:7][CH:8]=[CH:9][C:10]([O:12]C(C)(C)C)=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(Cl)Cl.FC(F)(F)C(O)=O>[C:1]1([CH2:7][CH:8]=[CH:9][C:10]([OH:12])=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 1

HCID 53401901t-Butyl 4-phenyl-2-butenoate

생성물 1

HCID 534018584-Phenyl-2-butenoic acid수율 99.85%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of 6.3 g (28.86 mmol) of t-butyl 4-phenylbut-2-enoate in 100 mL of CH2Cl2 and 30 mL of trifluoroacetic acid is stirred at 25° C. for 18 hours. The reaction is concentrated in vacuo to afford 4.67 g (99.85%) of 4-phenylbut-2-enoic acid as a yellow crystalline solid.

후처리

  1. concentrationThe reaction is concentrated in vacuo

출처 및 근거

ORD 기록
ord-6bf6f2351585416a8bfcb7d53d6549df
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06057369

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