Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromide ion → (2,6-Dichloro-3-methoxybenzyl)(triphenyl)phosphonium bromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromide ion | HCID 259 | — |
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | (2,6-Dichloro-3-methoxyphenyl)methanol | HCID 21980844 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Methane, dichloro-, compd. with benzene (1:1) | HCID 23443464 | — |
| 생성물 | (2,6-Dichloro-3-methoxybenzyl)(triphenyl)phosphonium bromide | HCID 87899066 | 97% |
반응 단계
Bromination of (2,6-dichloro-3-methoxyphenyl)methanol with 30% HBr in acetic acid, followed by reaction of the crude bromide with triphenylphosphine, using the procedure described in example 112, except that the reaction time for the displacement was 36 h, gave the phosphonium salt (526) (97%) as a white solid, mp (CH2Cl2/benzene) 242–244° C. 1H NMR (CDCl3) δ 7.83–7.60 (m, 15H), 7.15 (dd, J=9.1, 0.8 Hz, 1H), 6.88 (dd, J=9.0, 2.4 Hz, 1H), 5.41 (d, J=14.3 Hz, 2H), 3.84 (s, 3H). Found: C, 58.68; H, 4.16. C26H22BrCl2OP requires C, 58.67; H, 4.17.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07094798B1 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-45cd2ce8b12c4a538ef3a33a64d2aec4 |
| 출처 메모 | uspto-grants-2006_08 |