Menthol → Menthyl acrylate

HRID 1107238노트

반응식

HRID 1107238 반응식
[C:1]([OH:5])(=[O:4])[CH:2]=[CH2:3].[CH:6]1([CH3:16])[CH2:11][CH2:10][CH:9]([CH:12]([CH3:14])[CH3:13])[CH:8](O)[CH2:7]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[C:1]([O:5][CH:8]1[CH:9]([CH:12]([CH3:14])[CH3:13])[CH2:10][CH2:11][CH:6]([CH3:16])[CH2:7]1)(=[O:4])[CH:2]=[CH2:3]

참가 물질

5

반응물 3

HCID 1254MentholHCID 6101p-Toluenesulfonic acidHCID 6581Acrylic Acid

생성물 1

HCID 544164Menthyl acrylate

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
150 °C

실험 절차

26 g of acrylic acid, 24 g of menthol and 15 g of p-toluenesulfonic acid in 500 mL of toluene were heated under reflux at an oil temperature of 150° C. for 19 h. Subsequently, the reaction mixture was quenched by the addition of salt saturated sodium bicarbonate solution. The mixture was then extracted with ether, the organic layers were combined and washed with salt saturated sodium bicarbonate solution and then with an aqueous solution of sodium hydride, salt saturated ammonium chloride solution, and then dried over salt saturated brine and sodium sulfate anhydrous. Finally, the resultant oily product was evaporated under reduced pressure to obtain menthyl acrylate.

후처리

  1. customSubsequently, the reaction mixture was quenched by the addition of salt saturated sodium bicarbonate solution
  2. extractionThe mixture was then extracted with ether
  3. washwashed with salt saturated sodium bicarbonate solution
  4. dry with materialwith an aqueous solution of sodium hydride, salt saturated ammonium chloride solution, and then dried over salt saturated brine and sodium sulfate anhydrous
  5. customFinally, the resultant oily product was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-eb87e9a54fb34c629957135dd0006571
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06060207

반응 노트

불러오는 중…