Potassium Hydroxide → HCID 18786977, 화합물

HRID 1107381노트

반응식

HRID 1107381 반응식
C([O:3][C:4](=[O:23])[CH2:5][N:6]([CH3:22])[C:7](=[O:21])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH3:20])C.[OH-].[K+]>CO.O>[CH3:22][N:6]([C:7](=[O:21])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH3:20])[CH2:5][C:4]([OH:23])=[O:3]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 18786983HCID 18786983, 화합물

생성물 1

HCID 18786977HCID 18786977, 화합물수율 48.9%

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

N-methyl-N-[2-(methylphenyl)benzoyl]glycine ethyl ester (4.5 g, 14.45 mmol) and KOH (2.43 g, 43.4 mmol) in MeOH/H2O (200 mL/50 mL) were heated at reflux for 45 minutes. The solvent was removed and the residue dissolved in H2O. The aqueous solution was washed with Et2O and acidified with HCl (10%). The acidified aqueous layer was extracted with EtOAc, the EtOAc extract was washed with brine (2×), dried over (MgSO4) and evaporated. There was obtained N-methyl-N-[2-(methylphenyl)benzoyl]glycine (2.0 g); LRMS (M+H)+=284.1, (M+NH4)+=301.1

후처리

  1. temperatureat reflux for 45 minutes
  2. customThe solvent was removed
  3. dissolutionthe residue dissolved in H2O
  4. washThe aqueous solution was washed with Et2O
  5. extractionThe acidified aqueous layer was extracted with EtOAc
  6. extractionthe EtOAc extract
  7. washwas washed with brine (2×)
  8. dry with materialdried over (MgSO4)
  9. customevaporated

출처 및 근거

ORD 기록
ord-b4ed425bc6bb4fafbf4e415008c9c125
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06060462

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