Ammonia → (1-Phenylcyclohexyl)methanamine

HRID 1107439노트

반응식

HRID 1107439 반응식
[C:1]1([C:7]2([C:13]#[N:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CCO.N>C(Cl)Cl.[Rh]>[C:1]1([C:7]2([CH2:13][NH2:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

6

반응물 3

HCID 222AmmoniaHCID 702EthanolHCID 751481-Phenylcyclohexanecarbonitrile

생성물 1

HCID 205110(1-Phenylcyclohexyl)methanamine

시약·촉매·용매 2

HCID 23948Rhodium촉매HCID 6344Dichloromethane용매

실험 절차

A mixture containing 1-phenyl-1-cyclohexane-carbonitrile (5.0 g, 27.0 mmol), 150 ml of EtOH, 35 ml of ammonia and 5% rhodium on alumina (1.0 g) was reacted for 12 hours at 80° C. and 500 psi. The mixture was filtered and the filtrate was concentrated in vacuo to provide an oil. This oil was dissolved in CH2Cl2, washed with brine, dried over Na2SO4, filtered and then concentrated in vacuo.

후처리

  1. customwas reacted for 12 hours at 80° C.
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate was concentrated in vacuo
  4. customto provide an oil
  5. washwashed with brine
  6. dry with materialdried over Na2SO4
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-d56e7118374b4e1697b1196970ab8bfe
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06060484

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