7-Aminoindole → HCID 11100239, 화합물

HRID 1107443

반응식

HRID 1107443 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[CH:7]2.[S:11]([C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1)(=[O:14])(=[O:13])[NH2:12]>N1C=CC=CC=1>[NH:9]1[C:10]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[NH:1][S:21]([C:18]2[CH:17]=[CH:16][C:15]([S:11](=[O:14])(=[O:13])[NH2:12])=[CH:20][CH:19]=2)(=[O:23])=[O:22])[CH:7]=[CH:8]1

참가 물질

4

반응물 2

HCID 1116347-AminoindoleHCID 109561594-Sulfamoylbenzene-1-sulfonyl chloride

생성물 1

HCID 11100239HCID 11100239, 화합물수율 63.3%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

The synthesis of the present compound can be carried out according to the process disclosed in JP-A-7-165708. For example, the present compound can be synthesized as follows. After dissolving 264 mg (2 mmol) of 7-amino-1H-indole in pyridine, 767 mg (3 mmol) of 4-sulfamoylbenzenesulfonyl chloride is added thereto under stirring at room temperature. After the mixture is stirred overnight at room temperature, the solvent is evaporated under reduced pressure. Ethyl acetate and 0.2 N hydrochloric acid are added to the resulting residue. The organic layer is separated, washed with water, and dried over magnesium sulfate, followed by evaporation of the solvent. The resulting residue is purified by silica gel column chromatography to give 445 mg of N-(1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide.

후처리

  1. customThe synthesis of the present compound
  2. additionis added
  3. stirringAfter the mixture is stirred overnight at room temperature
  4. customthe solvent is evaporated under reduced pressure
  5. additionEthyl acetate and 0.2 N hydrochloric acid are added to the resulting residue
  6. customThe organic layer is separated
  7. washwashed with water
  8. dry with materialdried over magnesium sulfate
  9. customfollowed by evaporation of the solvent
  10. customThe resulting residue is purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-43a8760c721b4de49c9f488aa7441b9f
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06060498

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