[CH3:1][CH2:2][NH:3][CH2:4][CH2:5][NH:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([CH3:18])=[O:17])=[CH:11][CH:10]=1)=[O:8].[CH:19]1C=CC2N(O)N=NC=2[CH:24]=1.CCN=C=NCCCN(C)C>CN(C=O)C>[CH3:1][CH2:2][N:3]([CH2:4][CH2:5][NH:6][C:7]([C:9]1[CH:10]=[CH:11][C:12]([NH:15][C:16]([CH3:18])=[O:17])=[CH:13][CH:14]=1)=[O:8])[CH2:19][CH3:24]The N-Acetylprocainamide probe was prepared as follows: 1.0 mg desethyl-N-Acetylprocainamide was placed in a 3.0 ml reaction vial and dissolved with 100 μl DMF. In a separate vial, caged dicarboxy silicon phthalocyanine (1.0 mg) was dissolved in 400 μl DMF and then transferred to the reaction vial along with 200 μl of wash DMF for a total of 600 μl. To the reaction vial was added 4.2 mg HOBT, dissolved and mixed well. To make the final reaction mixture, 10.5 mg EDAC was added and mixed thoroughly. The reaction mixture was stirred overnight at about 4 to 8° C.
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