Hexadecylamine → N-(2-hydroxyethoxy)ethyl-n-hexadecylamine

HRID 1107605

반응식

HRID 1107605 반응식
[CH2:1]([NH2:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].Cl[CH2:19][CH2:20][O:21][CH2:22][CH2:23][OH:24].[OH-].[K+].C(O)C>C(O)C>[OH:24][CH2:23][CH2:22][O:21][CH2:20][CH2:19][NH:17][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

참가 물질

5

반응물 3

HCID 8926HexadecylamineHCID 123612-(Chloroethoxy)ethanolHCID 21946426Potassium hydroxide ethanol

생성물 1

HCID 9996690N-(2-hydroxyethoxy)ethyl-n-hexadecylamine수율 70%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Into a 1 l rounded-flask, were introduced 48.2 g of hexadecyl amine and 700 ml of ethanol. The mixture was heated to reflux, and then was gradually added 11 ml of 2-(2-chloroethoxy)ethanol. The mixture was refluxed for 3 hours and cooled to a room temperature. Thereto was added solution of KOH/ethanol to produce precipitates, which were removed by filtration. The filtrate was concentrated under reduced pressure, and then was recrystallized from ethanol, and dried to give 24.1 g of the title compound(Yield: 70%) as white powder, which was identified by IR and NMR. The results are shown in Table 1.

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux
  3. temperatureThe mixture was refluxed for 3 hours
  4. customto produce
  5. customprecipitates
  6. customwhich were removed by filtration
  7. concentrationThe filtrate was concentrated under reduced pressure
  8. customwas recrystallized from ethanol
  9. customdried

출처 및 근거

ORD 기록
ord-7b93908ad6e64715811b802693a3f15e
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06060612

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