Dimethylamine → 2-bromo-N,N-dimethylbenzylamine

HRID 1107724

반응식

HRID 1107724 반응식
[CH3:1][NH:2][CH3:3].[Br:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7]Br>CO>[Br:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7][N:2]([CH3:3])[CH3:1]

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 769652-Bromobenzyl bromide

생성물 1

HCID 747922-bromo-N,N-dimethylbenzylamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Dimethylamine (33% w/w in methanol) (25 ml) was added to 2-bromobenzylbromide (7.5 g 30 mmol) at 0° C. in methanol (35 ml), and the solution stirred for 30 min., evaporated, diluted with water and extracted twice with diethyl ether. The combined extracts were dried over sodium sulphate and evaporated to give product as a yellow oil (6.0 g). M+ 215/213; 360 MHz 1H n.m.r (CDCl3) 7.54 (1H, dd, J 1.2, 8.0 Hz), 7.42 (1H, dd, J 1.6, 7.6 Hz), 7.30-7.26 (1H, m), 7.11 (1H, dt, J 1.7, 7.7 Hz), 3.52 (2H, s), 2.30 (6H, s).

후처리

  1. customevaporated
  2. additiondiluted with water
  3. extractionextracted twice with diethyl ether
  4. dry with materialThe combined extracts were dried over sodium sulphate
  5. customevaporated

출처 및 근거

ORD 기록
ord-df42aafd75f442d2b8d83ab3dd190459
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06063789

연결된 노트

불러오는 중…