2-Thiophenemethanol → 1-(2-Butenyl)-2,3-dimethyl-7-(2-thienylmethyloxy)pyrrolo[2,3-d]pyridazine

HRID 1107758

반응식

HRID 1107758 반응식
[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4].[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[CH2:22][OH:23]>>[CH2:1]([N:5]1[C:9]2=[C:10]([O:23][CH2:22][C:18]3[S:17][CH:21]=[CH:20][CH:19]=3)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4]

참가 물질

3

반응물 2

HCID 694672-ThiophenemethanolHCID 537196241-(2-Butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine

생성물 1

HCID 544657941-(2-Butenyl)-2,3-dimethyl-7-(2-thienylmethyloxy)pyrrolo[2,3-d]pyridazine수율 20.6%

실험 절차

The title compound (cis/trans=20/80) was prepared as a grayish white powder in 20.6% yield in a similar procedure to that described in Example 1 by using 1-(2-butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine (cis/trans=20/80) and 2-thiophenemethanol.

출처 및 근거

ORD 기록
ord-c0a3d2e330cf4a70a473048bfac85874
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06063782

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