4-Fluorobenzylic alcohol → 1-(2-Butenyl)-7-(4-fluorobenzyloxy)-2,3-dimethylpyrrolo[2,3-d]pyridazine

HRID 1107759

반응식

HRID 1107759 반응식
[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4].[F:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22][OH:23])=[CH:20][CH:19]=1>>[CH2:1]([N:5]1[C:9]2=[C:10]([O:23][CH2:22][C:21]3[CH:24]=[CH:25][C:18]([F:17])=[CH:19][CH:20]=3)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4]

참가 물질

3

반응물 2

HCID 680224-Fluorobenzylic alcoholHCID 537196241-(2-Butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine

생성물 1

HCID 539969541-(2-Butenyl)-7-(4-fluorobenzyloxy)-2,3-dimethylpyrrolo[2,3-d]pyridazine수율 59.3%

실험 절차

The title compound (cis/trans=98/2) was prepared as pale brown crystals in 59.3% yield in a similar procedure to that described in. Example 1 by using 1-(2-butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine (cis/trans=94/6) and 4-fluorobenzyl alcohol.

출처 및 근거

ORD 기록
ord-22e0201958ff4fc5b27145f6886edb76
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06063782

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