4-(Difluoromethoxy)benzyl alcohol → 1-(2-Butenyl)-7-(4-difluoromethoxybenzyloxy)-2,3-dimethylpyrrolo[2,3-d]pyridazine

HRID 1107761

반응식

HRID 1107761 반응식
[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4].[F:17][CH:18]([F:28])[O:19][C:20]1[CH:27]=[CH:26][C:23]([CH2:24][OH:25])=[CH:22][CH:21]=1>>[CH2:1]([N:5]1[C:9]2=[C:10]([O:25][CH2:24][C:23]3[CH:22]=[CH:21][C:20]([O:19][CH:18]([F:17])[F:28])=[CH:27][CH:26]=3)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4]

참가 물질

3

반응물 2

HCID 27369964-(Difluoromethoxy)benzyl alcoholHCID 537196241-(2-Butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine

생성물 1

HCID 536828811-(2-Butenyl)-7-(4-difluoromethoxybenzyloxy)-2,3-dimethylpyrrolo[2,3-d]pyridazine수율 37.8%

실험 절차

The title compound (cis/trans=21/79) was prepared as a white powder in 37.8% yield in a similar procedure to that described in Example 1 by using 1-(2-butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine (cis/trans=20/80) and 4-difluoromethoxybenzyl alcohol.

출처 및 근거

ORD 기록
ord-55dac3f409764200bde777084ec3c99f
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06063782

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