3-Pyridinemethanol → 1-(2-Butenyl)-2,3-dimethyl-7-(3-pyridylmethyloxy)pyrrolo[2,3-d]pyridazine

HRID 1107762

반응식

HRID 1107762 반응식
[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4].[N:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][OH:24])[CH:18]=1>>[CH2:1]([N:5]1[C:9]2=[C:10]([O:24][CH2:23][C:19]3[CH:18]=[N:17][CH:22]=[CH:21][CH:20]=3)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4]

참가 물질

3

반응물 2

HCID 75103-PyridinemethanolHCID 537196241-(2-Butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine

생성물 1

HCID 542747031-(2-Butenyl)-2,3-dimethyl-7-(3-pyridylmethyloxy)pyrrolo[2,3-d]pyridazine수율 45.9%

실험 절차

The title compound (cis/trans=22/78) was prepared as a pale yellow powder in 45.9% yield in a similar procedure to that described in Example 1 by using 1-(2-butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine (cis/trans=20/80) and 3-pyridinemethanol.

출처 및 근거

ORD 기록
ord-c77aeee2fd294e5ca0504fb5d230a2c9
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06063782

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