Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromide ion → (2-Chloro-3-nitrobenzyl)(triphenyl)phosphonium bromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromide ion | HCID 259 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 2-Chloro-3-nitrotoluene | HCID 77591 | — |
| 반응물 | Nbs aibn | HCID 86630000 | — |
| 용매 | Methane, dichloro-, compd. with benzene (1:1) | HCID 23443464 | — |
| 생성물 | (2-Chloro-3-nitrobenzyl)(triphenyl)phosphonium bromide | HCID 87899071 | 44% |
반응 단계
Bromination of 2-chloro-3-nitrotoluene with NBS/AIBN, followed by reaction of the crude bromide with triphenylphosphine, using the procedure described in example 102, except that the reaction time for the bromination was 2 h and the displacement reaction was performed at 70° C. for 1 d, gave the phosphonium salt (554) (44%) as a light brown solid, mp (CH2Cl2/benzene) 224–228° C. 1H NMR (CDCl3) δ 8.09 (br d, J=8.3 Hz, 1H), 7.86–7.63 (m, 16H), 7.34 (t, J=8.1 Hz, 1H), 5.95 (d, J=14.6 Hz, 2H). Found: C, 58.68; H, 4.12; N, 2.79. C25H20BrclNO2P requires C, 58.56; H, 3.93; N, 2.73.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07094798B1 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-fa1cddeabd1848c58bbff604171a8e90 |
| 출처 메모 | uspto-grants-2006_08 |