Sulfuric Acid → 154205-24-0

HRID 1107973노트

반응식

HRID 1107973 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([CH3:14])[CH:13]=1)[NH:5][CH2:6][CH2:7][C:8](O)=O.S(=O)(=O)(O)[OH:16]>>[CH3:1][C:2]1[CH:13]=[C:12]([CH3:14])[CH:11]=[C:4]2[C:3]=1[CH:8]=[CH:7][C:6](=[O:16])[NH:5]2

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 24348423-[(3,5-Dimethylphenyl)amino]propanoic acid

생성물 1

HCID 22247325154205-24-0

실험 절차

β-(3,5-Dimethylanilino)propionic acid (1.2 g) was added by portions to sulfuric acid (60° C., 12 ml), and the mixture was stirred at the same temperature for 0.5 hr. The reaction mixture was poured into ice water (100 ml) and extracted with chloroform (100 ml). After washing with water, the chloroform layer was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/benzene=1/5-1/1) to give 750 mg of 5,7-dimethylquinolone as crystals.

후처리

  1. extractionextracted with chloroform (100 ml)
  2. washAfter washing with water
  3. dry with materialthe chloroform layer was dried over anhydrous sodium sulfate
  4. customThe solvent was evaporated under reduced pressure
  5. customThe residue was purified by silica gel column chromatography (eluent: ethyl acetate/benzene=1/5-1/1)

출처 및 근거

ORD 기록
ord-6bd2f627eadd445fa518cec2ca26787c
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06063806

반응 노트

불러오는 중…