Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 4'-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl][1,1'-biphenyl]-4-carbonyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | [1,1'-Biphenyl]-4,4'-dicarbonyl dichloride | HCID 75374 | — |
| 반응물 | N-Hydroxysuccinimide | HCID 80170 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4'-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl][1,1'-biphenyl]-4-carbonyl chloride | HCID 18407509 | 93.2% |
반응 단계
A solution of 1.67 g (6.0 mmol) of 11 in 65 mL of dry THF was treated with 710 mg (6.17 mmol) of N-hydroxysuccinimide, followed by 0.835 mL (6.0 mmol) of triethylamine. The reaction was stirred at room temperature for 2 hours after which time it was filtered to remove triethylamine HCl. The filtrate was concentrated at reduced pressure to yield 2.0 g (93%) of 12 as a pale yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06063908 |
| 출처 데이터셋 | uspto-grants-2000_05 |
| ORD ID | ord-61f6197dc95546399c5d531483c2f2d7 |
| 출처 메모 | uspto-grants-2000_05 |