CJ-13454 → 1-[5-Fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]cyclopentane-1-carboxamide
반응식
FC1C=C(C2(C(OCC)=O)CCCC2)C=C(OCC2C=CC(N3C=CN=C3C)=CC=2)C=1.[F:32][C:33]1[CH:34]=[C:35]([O:48][CH2:49][C:50]2[CH:55]=[CH:54][C:53]([N:56]3[CH:60]=[CH:59][N:58]=[C:57]3[CH3:61])=[CH:52][CH:51]=2)[CH:36]=[C:37]([C:39]2([C:45]([NH2:47])=[O:46])[CH2:44][CH2:43]O[CH2:41][CH2:40]2)[CH:38]=1>>[F:32][C:33]1[CH:34]=[C:35]([O:48][CH2:49][C:50]2[CH:51]=[CH:52][C:53]([N:56]3[CH:60]=[CH:59][N:58]=[C:57]3[CH3:61])=[CH:54][CH:55]=2)[CH:36]=[C:37]([C:39]2([C:45]([NH2:47])=[O:46])[CH2:44][CH2:43][CH2:41][CH2:40]2)[CH:38]=1참가 물질
3
실험 절차
The desired compound was prepared from ethyl 1-[3-fluoro-5-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]cyclopentane-1-carboxylate according to the preparation of 4-[5-fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide (Example 5).
출처 및 근거
- ORD 기록
- ord-cbe821a45e75430891ed1782031d8de9
- 출처 데이터셋
- uspto-grants-2000_05
- 특허 번호
- US06063928
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