Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromide ion → (2-Chloro-5-nitrobenzyl)(triphenyl)phosphonium bromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromide ion | HCID 259 | — |
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 2-Chloro-5-nitrobenzyl alcohol | HCID 555722 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Methane, dichloro-, compd. with benzene (1:1) | HCID 23443464 | — |
| 생성물 | (2-Chloro-5-nitrobenzyl)(triphenyl)phosphonium bromide | HCID 11844221 | 63% |
반응 단계
Bromination of (2-chloro-5-nitrophenyl)methanol with 30% HBr in acetic acid, followed by reaction of the crude bromide with triphenylphosphine, using the procedure described in example 112, gave the phosphonium salt (564) (63%) as a white solid, mp (CH2Cl2/benzene) 239–243° C. 1H NMR (CDCl3) δ 8.22 (br s, 1H), 8.07 (br d, J=8.7 Hz, 1H), 7.87–7.65 (m, 15H), 7.41 (d, J=8.9 Hz, 1H), 5.80 (d, J=14.8 Hz, 2H). Found: C, 58.56; H, 3.93; N, 2.73. C25H20BrClNO2P requires C, 58.47; H, 3.98; N, 2.66.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07094798B1 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-5ff65fcfe3074652ab6aafbfe9be302d |
| 출처 메모 | uspto-grants-2006_08 |