Bromine → 4-Bromo-7-methoxy-1-benzofuran-2-carbaldehyde

HRID 1108316노트

반응식

HRID 1108316 반응식
[CH:1]([C:3]1[O:4][C:5]2[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[CH:8][C:6]=2[CH:7]=1)=[O:2].C([O-])(=O)C.[Na+].[Br:19]Br>ClCCl>[CH:1]([C:3]1[O:4][C:5]2[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]([Br:19])[C:6]=2[CH:7]=1)=[O:2]

참가 물질

5

반응물 3

HCID 24408BromineHCID 517045Sodium AcetateHCID 34573107-Methoxy-1-benzofuran-2-carbaldehyde

생성물 1

HCID 187848644-Bromo-7-methoxy-1-benzofuran-2-carbaldehyde

시약·촉매·용매 1

HCID 6344Dichloromethane용매3회

실험 절차

2-Formyl-7-methoxybenzofuran (1.0 g) was stirred in dichloromethane (10 ml) under nitrogen at 0° C. Sodium acetate (1.4 g) was added followed by the dropwise addition of bromine (0.29 ml). Further dichloromethane (20 ml) was added to the mixture to facilitate stirring and the mixture was stirred overnight. The reaction mixture was diluted with dichloromethane (40 ml) and washed with water (30 ml). Drying over magnesium sulfate followed by removal of the solvent in vacuo gave a pale orange solid. Purification by flash chromatography on silica eluting with 10% ethyl acetate in hexane gave the title compound (0.50 g) as a beige solid.

후처리

  1. stirringthe mixture was stirred overnight
  2. washwashed with water (30 ml)
  3. dry with materialDrying over magnesium sulfate
  4. customfollowed by removal of the solvent in vacuo
  5. customgave a pale orange solid
  6. customPurification by flash chromatography on silica eluting with 10% ethyl acetate in hexane

출처 및 근거

ORD 기록
ord-7eb9a6b965734d07987a37983b422353
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06066657

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