Trifluoroacetic acid → 4-(4-Bromo-7-methoxybenzofuran-2-ylmethoxy)-piperidine

HRID 1108320노트

반응식

HRID 1108320 반응식
FC(F)(F)C(O)=O.C(OC([N:15]1[CH2:20][CH2:19][CH:18]([O:21][CH2:22][C:23]2[O:24][C:25]3[C:31]([O:32][CH3:33])=[CH:30][CH:29]=[C:28]([Br:34])[C:26]=3[CH:27]=2)[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[Br:34][C:28]1[C:26]2[CH:27]=[C:23]([CH2:22][O:21][CH:18]3[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]3)[O:24][C:25]=2[C:31]([O:32][CH3:33])=[CH:30][CH:29]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 540770204-(4-Bromo-7-methoxybenzofuran-2-ylmethoxy)-piperidine-1-carboxylic Acid tert-butyl Ester

생성물 1

HCID 187848694-(4-Bromo-7-methoxybenzofuran-2-ylmethoxy)-piperidine수율 97.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Trifluoroacetic acid (5 ml) was added to a stirred solution of 4-(4-bromo-7-methoxybenzofuran-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester (1.3 g) in dichloromethane (50 ml). After stirring at room temperate overnight the reaction was diluted with dichloromethane (150 ml) washed with 1M sodium hydroxide (100 ml) and dried over magnesium sulfate. The organic phase was concentrated in vacuo to afford the title compound as a pale yellow gum (0.98 g).

후처리

  1. washwashed with 1M sodium hydroxide (100 ml)
  2. dry with materialdried over magnesium sulfate
  3. concentrationThe organic phase was concentrated in vacuo

출처 및 근거

ORD 기록
ord-ce50eecc609e43c3b6455bd48d38dc13
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06066657

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