Methylglyoxal → 3-Methoxy-5-methylpyrazine-2-carboxamide

HRID 1108446

반응식

HRID 1108446 반응식
[NH2:1][CH:2]([C:6]#[N:7])[C:3]([NH2:5])=[O:4].[CH3:8][O-:9].[Na+].[CH3:11][C:12]([CH:14]=O)=O>CO>[CH3:8][O:9][C:6]1[C:2]([C:3]([NH2:5])=[O:4])=[N:1][CH:14]=[C:12]([CH3:11])[N:7]=1

참가 물질

5

반응물 3

HCID 880MethylglyoxalHCID 983412-Amino-2-cyanoacetamideHCID 10942334Sodium Methoxide

생성물 1

HCID 110627763-Methoxy-5-methylpyrazine-2-carboxamide수율 229%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
20 °C

실험 절차

Under argon, 6 g (60.5 mmol) of 2-amino-2-cyanoacetamide was initially charged in 67 g of methanol. 1.67 g (9.3 mmol) of sodium methoxide solution (30%) was added and the mixture was stirred at 20° C. for 2 hours. At 0° C., 11.55 g (64.1 mmol) of methylglyoxal solution (40%) was added and the mixture was stirred at 0° C. for 2 hours. The solution was then cooled to -20° C. The product precipitated out. After filtration and drying, 3.56 g of the title product was obtained. The yield was 39 percent. The melting point of the title product was 170° C. to 172° C. Other data concerning the title product was:

후처리

  1. stirringthe mixture was stirred at 0° C. for 2 hours
  2. temperatureThe solution was then cooled to -20° C
  3. customThe product precipitated out
  4. filtrationAfter filtration
  5. customdrying

출처 및 근거

ORD 기록
ord-3a6534d12689498b86c2dbd29d1ec24c
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06066736

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